419 papers
Cell biology is the study of life at its most fundamental unit: the cell. This field explores how these microscopic building blocks function, communicate, and replicate to sustain living organisms, from the simplest bacteria to complex human tissues. By understanding the machinery inside a cell, scientists unlock secrets about growth, disease, and the very nature of existence itself.
At Gist.Science, we track every new preprint uploaded to bioRxiv within this dynamic category. Our team processes each submission to provide both accessible plain-language explanations and detailed technical summaries, ensuring you can grasp complex discoveries without getting lost in dense jargon. Below are the latest papers in cell biology, offering a fresh look at the inner workings of life as they are shared with the world.
This study demonstrates that in *Schizosaccharomyces pombe*, PAK-family kinases (primarily Pak2) ensure irreversible cell fusion by accumulating at the fusion site to antagonize cell wall repair mechanisms, thereby preventing the resealing of the fusion pore and the catastrophic reversion to a haploid state.
Leptin Receptor-expressing stromal cells in the bone marrow create a specialized perisinusoidal niche for thrombopoiesis by secreting CXCL14, which remodels lipid metabolism in megakaryocytes to facilitate their terminal differentiation into platelets.
This study demonstrates that EXOC6A, through its interaction with myosin-Va and dynein-dependent transport, orchestrates vesicle dynamics and membrane remodeling to facilitate ciliogenesis and the assembly of transition zone components.
This study demonstrates that bacterial extracellular vesicles do not directly disrupt a human stem cell-derived blood-brain barrier on-chip but instead indirectly compromise its integrity by stimulating immune cells to release pro-inflammatory cytokines that degrade tight junctions.
This study utilizes knockout mouse models to define the proteomic composition and mutual assembly requirements of the vertebrate C2a projection, revealing that its components (including newly identified ARMC3 and MYCBP) are interdependent for structural stability and that their dysfunction leads to primary ciliary dyskinesia phenotypes.
This study demonstrates that while short-term arsenic exposure increases PML SUMOylation without altering nuclear body morphology, prolonged exposure at environmentally relevant concentrations stabilizes extranuclear PML bodies (EnPBs) in a low-solubility, non-SUMOylated state, highlighting distinct biological differences between nuclear and extranuclear PML structures.
This study demonstrates that the biosynthesis pathway of resolvin D and E is activated during cellular senescence and ageing, where it plays a functional role in inducing senescence and is modulated by small extracellular vesicles from young donors to ameliorate inflammation.
This study reveals that in budding yeast, the Mps1 kinase drives unattached kinetochore clustering to promote microtubule capture by phosphorylating conserved MELT motifs in Stu1, thereby recruiting Slk19 to form filamentous structures.
This study presents a microfluidic human fallopian tube-on-a-chip model lined with primary cells that recapitulates in vivo tissue folds and sperm reservoir function, demonstrating its utility for preclinical evaluation of non-hormonal contraceptives like TDI-11861 through dose-dependent inhibition of sperm motility.
This study utilizes budding yeast to demonstrate that furanic Maillard reaction products (HMF, FUR, and FMK) exhibit distinct uptake, efflux, and toxicity mechanisms, with HMF and FUR specifically linked to nutrient transporter levels and causing damage to mitochondria and the endolysosomal system, respectively.